Students will examine the chemical structure of caffeine molecules and use the HPLC to generate a calibration curve using caffeine standards. Students will then prepare samples of coffee containing unknown amounts of caffeine and use the HPLC to determine the amount of caffeine in each sample. They will then compare the results to the recommended daily amount from the Mayo Clinic.

Program objectives:

  • Accurately transferring liquids using a micropipette.
  • Accurately preparing standards to be used to construct a calibration curve.
  • Preparing dilutions to perform HPLC analysis of instant coffee samples.
  • Using retention times to correctly identify the correct caffeine peak from the HPLC results.

Duration:

3 hours

Capacity:

24 students